Hinsberg Synthesis of Thiophene Derivatives I carboxylic acids I Reaction I Chemical Reaction

O. Hinsberg, Ber. 43, 901 (1910).
Formation of thiophene carboxylic acids from ?-diketones and dialkyl thiodiacetates:

Hinsberg Synthesis of Thiophene Derivatives
H. Wynberg, D. J. Zwanenburg, J. Org. Chem. 29, 1919 (1964); H. Wynberg, H. J. Kooreman, J. Am. Chem. Soc. 87, 1739 (1965); A. Birch, D. A. Crombie, Chem. Ind. 1971, 177; D. J. Chadwick et al., J. Chem. Soc. Perkin Trans. I 1972, 2079


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