What is meant Chromosomes are: Chromosomes are a structure that contains the DNA macromolecule in which genetic information is stored in the cell.The so-called "aneuploidy" can lead to cancer, thus confirming what has long been suspected by scientists, according to some research findings.
Essentially all human cancers have a number of abnormal chromosomes, and scientists have long suspected that the gene mutations that promote the separation of chromosomes during cell division wrong is the cause of development of tumors, said researchers at the Mayo Clinic, said in a statement, which was broadcast on Monday (7 / 12)
"By using a combination of new mouse models for human cancer, we can prove that aneuploidy cause cancer and reveal the mechanism of this process," says cancer biologist at the Mayo Clinic and the study's senior author, Jan van Deursen, as reported French news agency, AFP .
In trials on mice, the researchers found that one cell is less able to suppress tumors when there is mitotic or cleavage of the chromosome, which generate misalignment or misintegrasi, when one cell is missing chromosomes.
"These cells are losing the ability to suppress tumors, which became part of the immune system," said Mayo Clinic spokesman, Bob Nellis.
"It's like the loss of the device anti-virus software on your computer," said Mayo Clinic spokesman, Bob Nellis.
"These cells are more likely to say,` Come and catch me `to cancer," he said.
Is chromosome aberration depends on the cause of cancer genetics or family history of the person concerned and the type of cancer, says Nellis.
Among the cancers found in the study was triggered by the "aneuploidy" is a colon cancer and cancers of the lymph system network.
The findings, published in the journal "Cancer Cell published today, ending a long debate in the field of cancer research as to whether" aneuploidy "is a cause of cancer, or caused by it.
"Because we now understand the mechanisms that allow cancer resulted in aneuploidy, it will be easier for other researchers to build this knowledge, and new drugs targeting the match," said van Deursen, in a statement.
In the other study, published in the "Journal of Cell Biology", Monday, researchers at the National Cancer Institute (NCI) "examine the possibility that a particular disease gene arrangement may be utilized as a new diagnostic strategies to distinguish the malignant tissue with normal".
The researchers found several genes in the malignant breast cancer tissue has a different position in the cell nucleus compared to that which occurred in the normal breast tissue.
They also found that the position of a single gene, HES5, allowing them to identify malignant breast cancer tissue "with nearly 100 percent accuracy".
The findings in these studies leave open the possibility of using a gene's position in the cell nucleus as a new diagnostic tool, although the authors acknowledge that larger studies must be done first.
They study a series of 20 genes studied in 11 cells in normal human breast tissue and 14 specimens of malignant breast cancer.
"If validated in larger quantities, we predict that this approach is probably the first molecular clues about cancer benefit after mammogram lack of normality," said Tom Misteli of the "Center for Cancer Research" at the NCI. He also is the senior author of the study.
Use of one's position within the core gene to detect tumor cells can "reduce human error in making the diagnosis because these methods provide a lot of notes and not based on subjective or expertise kriteris individual pathology assessment by using a microscope," the study said.
New diagnostic tool is not limited to breast cancer, but can be applied to any cancer - current conditions aberrant gene can be identified, said Misteli. Excerpt from: Between
