Packed in the inert atmosphere.
A less toxic, solid, synthetic derivatives of benzo-quinone ansamycin antibiotic Geldanamycin, Streptomyces hygroscopicus (Cat. No. 345805), based on Hsp90 (EC50 = 7.2 mm) and set the functions.
Induced apoptosis and showed anti-tumor effect (IC50 = 4.1 nm in SKBR3 and 5.2 nm in MCF7 cells). Out cancer cells erbB-1, erbB-2 (EC50 = 45 nm), mutant p53 (EC50 = 62 nm), Raf-1 (EC50 = 80 nm) and thus Akt inhibits the Ras / Raf / Mek and PI3-kinase signaling path.
Also sensitized cancer cells to paclitaxel (Cat. No. 580555) and doxorubicin (Cat. No. 324380) and downregulates vascular endothelial growth factor expression.
Purity: ≥ 98% by HPLC.
Dissolved in DMSO or MeOH.
CAS 75747-14-7, M.W. 585.7.
Ref.:
Bas, A.D., et al. 2002. Oncogene 21, 1159, Clarke, each year, et al. 2000. Oncogene 19, 4125, Schulte, TW, and Necker, LM 1998. Cancer Chemother. Pharmacol.
42, 273; cord R.C., et al. 1995. J. Med. Chem 38, 3806.
Protect from light.
A service provider ion, a stable complex with divalent cations. Useful to improve
intracellular Ca2 + levels. Also known as an uncoupler of the inhibitor and oxidative phosphorylation of mitochondrial ATPase activities.
With a weak antibiotic activity against Gram-positive bacteria.
Purity: ≥ 98% by TLC.
Dissolved in DMSO or MeOH.
For use in Aqueous systems, preparation of 100-mm stock in DMSO is recommended. Microliter amount of this solution can be defined in the H2O mixing quickly (eg 10 ml in 5 ml H2O). Aqueous in the system, which aggregates over time ionophore.
RTECS DM4676000,
CAS 52665-69-7, M.W. 523.6.
Ref.:
Merck Index 13, 1639, Leslie Caron, L.A., et al. 1994. FASEB J. 8, 639; M.J. Saunders and Hepler, P.K. 1982. Science 217, 943; journalist, B.C. 1976. Annu. Rev.
Biochem. 45, 501; Pfeiffer, D.R., et al. 1974. Biochemistry 13, 4007, Reed, PW, and oily, HA 1972. J. Biol. Chem 247, 6970.
Risk and Safety Statement: R: 20/21/22 S: 26-36/37/39
