Clearly, more Notice Extrahepatic bile Duct Cancer Risk Factors
Here are some possible risk factors for extrahepatic bile duct cancer:
* Having ulcerative colitis or chronic diseases of liver and bile duct
* History of Primary Sclerosing Cholangitis (PSC): This is thought to be autoimmune disorder, in which the body attacks its own cells inflammatory bile ducts. PSC cause scarring and progressive narrowing of the bile ducts, bile from the block to reach the intestines. Many patients eventually develop liver failure, necessitating a liver transplant. About 10 to 20 percent of patients with PSC will develop bile duct carcinoma. It is thought that the progressive epithelial regeneration after injury and predisposes patients with PSC to carcinoma. More than half of patients with PSC have a history of another autoimmune disorder, Idiopathic inflammatory bowel disease.
* Congenital abnormalities (abnormalities born with one) of the bile ducts: These include choledochal cysts (dilatation of common bile duct) and Caroli's disease (dilatation of the intrahepatic bile ducts). It is thought that prolonged sludging of bile in the dilated spaces, and after infection, a tendency for patients with progressive carcinoma epithelial injury and repair. Overall the risk of cholangiocarcinoma in patients about 10 percent.
* Tumors of benign bile ducts: These include bile duct adenomas (one tumor) or bile duct papillomatosis (multifocal)
* Hepatobiliary parasitic infections: These cases are the most commonly seen in the Far East and include Clonorchis sinensis (most prevalent in Japan, Korea, and Vietnam) and Opisthorchis viverrini (most prevalent in Thailand, Laos, and Malaysia). Clonorchis that when people eat freshwater fish that harbor the Clonorchis cyst. Cysts that develop into flukes (flatworms) in the friendly confines of the human intestine, and increased from duodenum (the first part of the intestine) into the general bile duct, where they mature. Carriage of this worm imparts a 25-50 risk of biliary tract carcinoma.
* Toxic exposure: Thorium dioxide (Thorotrast), a contrast dye is used as a radiologic procedures between 1930 and 1950, has been shown to promote cancer in the liver and bile ducts.
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