Gastritis can cause peptic ulcers and bleeding in the stomach. Some forms of chronic gastritis may increase the risk of gastric cancer, especially if there is a continuous thinning of the walls of the stomach and changes in the cells of the stomach wall.
Most gastric cancers are adenocarcinomas, which begins in glandular cells in the mucosa. Adenocarcinomas type 1 infection usually occurs due to H. pylori. Other types of cancer associated with infection by H. pylori is the MALT (mucosa-associated lymphoid tissue) lymphomas, the cancer is growing slowly at the immune system tissue in the stomach wall. This type of cancer can be cured if found at an early stage.
Gastritis therapy depends on the specific causes and may require changes in lifestyle, medication or, in rare cases, surgery to treat it.
Stomach acid irritates inflamed tissue in the stomach and cause pain and inflammation is more severe. That is why, for most types of gastritis, treatment involves medications that reduce or neutralize stomach acid such as:
1. Antacids. Antacids are drugs that can be liquid or tablet form and is a drug commonly used to overcome mild gastritis. Antacids neutralize stomach acid and can eliminate the pain caused by stomach acid quickly.
2. Acid inhibitors. When antacids are no longer able to cope with the pain, your doctor will probably recommend a medication such as cimetidin, ranitidine, famotidine nizatidin or to reduce the amount of stomach acid produced.
3. Proton pump inhibitor. More effective ways to reduce stomach acid is to shut the acid pumps in the cells of the stomach producing acid. Proton pump inhibitors reduce acid by closing the work of these pumps. Which include drug class is omeprazole, lansoprazole, rabeprazole and esomeprazole. These drugs also inhibit the type of work H. pylori.
4. Cytoprotective agents. The drugs in this group can help to protect the tissues that line the stomach and small intestine. Belonging to it is sucraflate and misoprostol. If taking medications regularly AINS (for some reason), doctors usually recommend taking drugs of this class. Cytoprotective other agents are bismuth subsalicylate also inhibits activity of H. pylori.
Therapy against H. pylori
There are several regimens in overcoming infections H. pylori. The most commonly used is a combination of antibiotics and proton pump inhibitor. Sometimes also added subsalycilate bismuth. Antibiotics work to kill bacteria, a proton pump inhibitor serves to ease the pain, nausea, heals inflammation and improve the effectiveness of antibiotics.
Therapy against infection H. pylori does not always work out, speed to kill H. pylori is very diverse, depending on the regimen used. However, the combination of three drugs seems more effective than the combination of two drugs. Therapy in the long term (over 2 weeks of therapy compared with 10 days) also appear to increase effectiveness.
